Mechanosensitive channels
A 24-month post-doctoral position in the area of ion channel physiology funded by the French
National Research Agency (ANR) is available starting April 2010. The host group "Membrane
Transporters and Signalling" (http://www.isv.
belong to the "Institut des Sciences du Végétal" (ISV) located on the CNRS campus of Gif sur
Yvette, at
Although plants respond to a wide variety of mechanical stimuli, and many mechanosensitive
channel activities have been characterized in plant membranes using the patch-clamp method, the
molecular nature of mechanoperception in plant systems has remained elusive. We recently showed
that the MSL9 and MSL10 proteins relatives of the E. coli MscS (Mechanosensitive channel of
Small conductance) might function cooperatively and provide mechanosensitive channel activities
at the plasma membrane of Arabidopsis root cells (Curr. Biol., 18: 730-734, 2008; Plant Signaling
& Behavior, 3: 726-729, 2008).
The first objective of the project is to characterize the electrophysiologica
MSL10 and other members of the MSL family (homologous system and bilayer). This part will be
done in close collaboration with A. Ghazi 's lab (IBBMC, Orsay). The second objective will be to
enlighten the functions of the MSL channels as sensor of vibrations in aerial part of the plant. This
will be conducted by a multidisciplinary approach involving, electrophysiology, molecular biology
and modelling in cooperation with other partners of the project.
Salary ~ 2000€/month
Applicants should hold a PhD and have preferably an experience in electrophysiology and,
possibly, in molecular biology. A background in plant biology would be an added value but is not
required. English but not French is required.
Candidates should send a CV with a brief summary of research experience, a list of publications
and the names and addresses of 3 contact information referees to Jean-Marie Frachisse
(frachisse@isv.
http://id-scholarships.blogspot.com/
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