Thursday, June 6, 2013

[beasiswa] [info] PhD position in Molecular Biology – Epigenetics of drug disposition & response

 

Dear all,

FYI,

http://ec.europa.eu/euraxess/index.cfm/jobs/jobDetails/33865649

In the field of "Epigenetics of drug disposition and response" the research group of Prof. Dr. Leszek Wojnowski at the Mainz University Medical Center offers the following PhD project:

Long-term memory and transgenerational propagation of the PXR- and CAR-mediated induction status

Description

We have a long-standing interest in the adaptive responses mediated by the xenosensors PXR and CAR and by their target genes such as CYP3A.The first objective of this project is to assess the scope of long-term epigenetic memory among the transcriptional targets of PXR and CAR. The second, objective is to find out if the expression status of PXR and CAR targets is transmitted to the offspring. These questions will be answered in adult mice treated shortly after birth with PXR and CAR activators, and in the offspring of these mice. The global hepatic induction status will be determined by next-generation mRNA sequencing and correlated to epigenetic marks such as histone modifications. Depending on the results, subsequent objectives will address 1) the possibility that long-term epigenetic memory contribute to the inter-individual variability in drug metabolizing capacity both in the exposed individuals and in their offspring, 2) that this memory may contribute to metabolic disorders such as osteopenia and diabetes previously associated with chronic exposure to PXR and CAR activators, 3) the evolutionary significance of long-term epigenetic memory among targets of xenobiotic receptors and 4) mechanisms of long-term epigenetic memory, including the elusive determinants of its transmission via the germline.

We offer

• The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team
• A stimulating, diverse and international research environment
• Advanced training opportunities
• A competitive stipend

Required qualifications

• Master or Diploma
• Motivation to solve complex biological problems
• Excellent communication skills

Starting date: 1 October 2013 or later
Duration of stipend: 3 years, with the possibility of extension
Deadline for applications (exclusively online via web form): 1 July 2013

Nr of positions available : 1

Research Fields

Biological sciences
Medical sciences

Career Stage

Early stage researcher or 0-4 yrs (Post graduate)

Research Profile

First Stage Researcher (R1)

Comment/web site for additional job details

For further questions and contact information please check our website:

http://www.imb-mainz.de/PhD


salam,
Ningrum

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