Post-doctoral position at the Cochin Institute, Paris :
Fellowship of the « Région Ile-de-France » (18 months starting September 2010 with
possibility of extension for 6-12 months). The candidate should possess a strong
back-ground in molecular biology (DNA cloning, etc..).
Project : Study of O-GlcNAc glycosylation of FoxO1 the betapancreatic
Cell
O-GlcNAc glycosylation of cytosolic and nuclear proteins constitutes a reversible
post-translational modification, analogous to phosphorylation, which now
appears as a major player in the regulation of cell signalling. This modification
depends on glucose concentrations, allowing a regulation of protein activities
according to the metabolic environment of the cell. O-GlcNAc modification could
therefore participate in the deleterious effects associated with chronic
hyperglycaemia observed in diabetes (glucotoxicty).
The transcription factor FoxO1 plays a major role in important biological processes
such as regulation of energy metabolism as well as cell proliferation and
apoptosis, notably in pancreatic beta-cells.
Our team was the first to demonstrate that FoxO1 is O-Glycosylated, resulting in an
increase in its transcriptional activity in liver cells. More recently, we have observed
that FoxO1 is also O-glycosylated in pancreatic beta-cells. This mechanism could
play a crucial role in pancreatic glucotoxicity, by inducing the apoptosis of the beta
cells.
The objective of this project will be to determine the consequences of O-GlcNAc
glycosylation of FoxO1 in pancreatic beta-cells. The project involves the use of betapancreatic
cell lines, isolated pancreatic islets as well as inducible FoxO1 KO
animals.
Please send by E-mail, CV, motivation letter, list of publications and names, E-mail
addresses, and telephone n° of 3 references at:
Dr. Tarik ISSAD,
Institut Cochin, Departement of Endocrinology, Metabolism and Cancer
Team « Glucose and insulin signalling, and Glucotoxicity »
E-mail: tarik.issad@inserm.fr
http://id-scholarships.blogspot.com/
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